Performance Collagen
Performance Collagen
Fortigel hydrolyzed collagen is a novel ingredient aimed at joint cartilage regeneration, backed by clinical evidence for reducing pain, enhancing mobility, and promoting long-term cartilage health safely.
Collagen’s significance extends to skin elasticity and hydration; potentially enhancing skin moisture, elasticity, and reduce wrinkles for a more youthful appearance.
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Cellular Pathways
A positive effect of collagen peptides on the regeneration of hyaline cartilage was observed in cultured chondrocytes.
The stimulation of the extracellular matrix (ECM) synthesis is probably caused by specific Hyp-Pro-Gly containing peptides with a molecular size <10 kD.
Stimulate the growth and activity of fibroblasts, the cells responsible for producing collagen in the skin and other connective tissues.
Why this matters:
As individuals age, collagen levels decrease, leading to less flexible and more brittle cartilage. Agingrelated changes increase collagen cross-linking, stiffening cartilage and making it prone to fatigue failure. Structural collagen changes, including degradation, are associated with skin wrinkling, bone deterioration, and cardiovascular and respiratory issues. Cartilage degeneration, a result of aging, can lead to arthritis, also known as degenerative joint disease.
Clinical Studies
Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides.
- 5g supplementation of FORTIGEL treatment was shown to decrease knee pain and stiffness and increase physical function after 6 weeks
- After 12 weeks 40% of patients reported no knee pain and 70% achieved a positive effect of therapy

Synergy with Pentosan Polysulfate, BPC-157, GHK-Cu
Performance Collagen™ + Pentosan Polysulfate
Hydrolyzed Collagen is a key component in proteoglycans and collagen type II formation which can help repair cartilage degradation and decrease joint pain, typically used in joint and inflammatory pain protocols.
Performance Collagen™ + BPC-157 and Sermorelin
Collagen supplementation when broken down can form foundational building blocks for muscle and ligament repair. Sermorelin improves growth hormone secretion while BPC-157 has been shown to upregulate growth hormone receptors. These have been used in synergy to improve injury and recovery.
Performance Collagen™ + GHK-Cu
Collagen supplementation helps rejuvenate collagen type III in the skin which is important for skin elasticity and overall skin health. GHK-Cu has been shown to enhance skin elasticity.
References
- Zdzieblik D, Oesser S, Gollhofer A, König D. Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides. Appl Physiol Nutr Metab. 2017 Jun;42(6):588-595. doi: 10.1139/apnm-2016-0390. Epub 2017 Jan 24. Erratum in: Appl Physiol Nutr Metab. 2017 Nov;42(11):1237. PMID: 28177710.