DHH-B

DHH-B

Dihydrohonokiol (DHH-B) is a natural compound extracted from magnolia bark, known for its anxiolytic effects. It promotes a sense of calm without causing motor dysfunction, amnesia, or physical dependence. Unlike synthetic drugs, DHH-B doesn’t exacerbate side effects or lead to withdrawal symptoms.
As a potent form of honokiol, it offers a natural alternative for anxiety and stress management.

SUBSCRIPTION PRICE
DETAILS
SUPPLEMENT FACTS

Per Bottle
60 capsules
Serving Size
1
Directions
Take 1 capsule daily

Amount per serving

Dihydrohonokiol-B (DHH-B) (Magnolia Bark)

15mg t

† Daily Value (DV) not established 
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Cellular Pathways

Chronic administration of honokiol, a natural compound, results in the buildup of a metabolite called dihydrohonokiol-B (DHH-B), which is responsible for honokiol’s anxiolytic (anxiety-reducing) effects. DHH-B acts as a potent agent to reduce anxiety by targeting the GABA_A receptor-gated chloride channel complex in the brain, suggesting a specific mechanism through which DHH-B can alleviate anxiety.

Why this matters:

Magnolia bark and its extracts need to be administered repeatedly to achieve their effects, whereas DHH-B (dihydrohonokiol-B) provides immediate anxiety-reducing benefits. Unlike benzodiazepines, a common class of anxiolytics, DHH-B does not lead to motor dysfunction or dependency. This underlines DHH-B’s promise as a therapeutic option for anxiety disorders, showcasing its capacity to alter neurotransmitter systems for effective anxiolytic outcomes without the significant side effects associated with many traditional medications.s

Clinical Studies

Honokiol, a putative anxiolytic agent extracted from magnolia bark, has no diazepam-like side effects in mice

  • Anxiety-reducing effects without affecting motor activity or muscle tone
  • Honokiol did not exhibit withdrawal symptoms seen with benzodiazepines
  • Honokiol did not disrupt learning, memory or central nervous system depression at anxiolytic doses

Synergy with Oxytocin, Sermorelin, GLP-1

DHH-B + Oxytocin

Oxytocin has been shown to decrease stress by its ability to reduce cortisol while DHH-B also has an anxiolytic effect by stimulating gaba receptors and manage stress and anxiety

DHH-B + Sermorelin

DHH-B helps patients manage sleep patterns. Typcially used with Sermorelin which improves night time growth hormone secretion that has been shown to enhance deep sleep.

DHH-B + GLP-1

Cortisol has been shown to be anabolic to fat tissue and catabolic to muscle tissue putting effective weight loss on hold. The combination of GLP-1 with DHH-B has been used to mitigate stress-induced weight loss resistance.

References

  1. Yuji Maruyama, Hisashi Kuribara, Eiko Kishi, Susan T Weintraub, Yoshihisa Ito, Confirmation of the anxiolytic-like effect of dihydrohonokiol following behavioural and biochemical assessments, Journal of Pharmacy and Pharmacology, Volume 53, Issue 5, May 2001, Pages 721–725, https://doi.org/10.1211/0022357011775848
  2. Poivre M, Duez P. Biological activity and toxicity of the Chinese herb Magnolia officinalis Rehder & E. Wilson (Houpo) and its constituents. J Zhejiang Univ Sci B. 2017;18(3):194-214. doi:10.1631/jzus.B1600299
  3. Mikhail Alexeev, Denise K. Grosenbaugh, David D. Mott, Janet L. Fisher, The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors, Neuropharmacology, Volume 62, Issue 8, 2012, Pages 2507-2514, ISSN 0028-3908, https://doi.org/10.1016/j.neuropharm.2012.03.002.