Apigenin is a flavonoid shown to influence weight, inflammation, and insulin resistance by altering the gut microbiota. Apigenin supplementation was shown to restore the richness and diversity of the gut microbiota akkermansia municiphila, a bacteria that have been associated with a decrease in plasma glucose, triglyceride, and body weight. Apigenin inhibits CD38, a key enzyme involved in the age-related decline of NAD+. CD38 is responsible for NAD decline and mitochondrial dysfunction. CD38 also metabolizes the NAD precursor NMN and modulates the response to NAD-replacement therapy.
