Sytrinol® LNA™

Sytrinol® LNA™

As an alternative to statins, Sytrinol®LNA leverages the synergy of leucine and nicotinic acid with polymethoxylated flavones and tocotrienols to manage lipid biomarkers, fat oxidation, and circadian rhythms.
The axis between SIRT1/NAD+/AMPK is the focus of Sytrinol® LNA and its ability to manage metabolism and dyslipidemia.

SUBSCRIPTION PRICE
DETAILS
SUPPLEMENT FACTS

Per Bottle
90 capsules
Serving Size
3
Directions
Take 3 capsules in the morning with food.

Amount per serving

Niacin (as Nicotinic Acid)

75mg NE t

L-Leucine

1100mg t

Sytrinol® (Proprietary Blend of Citrus Sinensis Extract and Elaeis Guineensis Extract)

300mg t

† Daily Value (DV) not established 
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Cellular Pathways 

3 main components of the supplement Leucine + Nicotinic acid + Sytrinol work on AMPK-NAD+-SIRT 1 Axis

Atherosclerosis Reduction

The proposed mechanism of reducing atherosclerosis by leveraging the SIRT1-NAD+-AMPK axis through Leucine and nicotinic acid combination.

Why this matters:

SIRT-1 Downstream Effects

Exercise positively impacts atherogenic lipids, which is a known biomarker for predicting cardiovascular disease risk. Leucine nicotinic acid + Sytrinol®LNA converges on these exercise pathways that have an effect on atherogenic lipids. For this reason, Sytrinol®LNA has become foundational in treatment plans addressing cardiovascular risk and metabolic syndrome.

Clinical Studies

Sytrinol Results

Effect of citrus flavonoids and tocotrienols on serum cholesterol levels in hypercholesterolemic subjects.

*James M Roza1, Zheng xian-Liu, Najia Guthrie Affiliations + ExpandPMD: 17985810

  1. Sytrinol significantly improved cardiovascular parameters compared to placebo in all groups.
  2. Significant reductions were shown in apolipoprotein B 21%

Synergy with GLP-1 + GIP: Sytrinol®LNA

Therapy with a focus on reducing cardiovascular risk.

Combining GLP-1, Growth hormone secretagogues, and mitochondrial compounds to converge on key metabolic pathways.

Tirzepatide (GLP-1 + GIP) + Sytrinol®LNA

GIP component improves healthy expansion of white adipose tissue to prevent spillover of dietary lipids that can cause ectopic lipid accumulation. Tirzepatide shown to reduce Triglycerides and VLDL

References

  1. Kim YJ, Choi MS, Woo JT, Jeong MJ, Kim SR, Jung UJ. Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity. Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600889. Epub 2017 Mar 2. PMID: 28116779.
  2. He B, Nohara K, Park N, Park YS, Guillory B, Zhao Z, Garcia JM, Koike N, Lee CC, Takahashi JS, Yoo SH, Chen Z. The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome. Cell Metab. 2016 Apr 12;23(4):610-21. doi: 10.1016/j.cmet.2016.03.007. PMID: 27076076; PMCID: PMC4832569.
  3. Zemel MB. Modulation of Energy Sensing by Leucine Synergy with Natural Sirtuin Activators: Effects on Health Span. J Med Food. 2020 Nov;23(11):1129-1135. doi: 10.1089/jmf.2020.0105. Epub 2020 Aug 4. PMID: 32758058.
  4. Bruckbauer A, Banerjee J, Cao Q, Cui X, Jing J, Zha L, Li F, Xue B, Shi H, Zemel MB. Leucine-nicotinic acid synergy stimulates AMPK/Sirt1 signaling and regulates lipid metabolism and lifespan in Caenorhabditis elegans, and hyperlipidemia and atherosclerosis in mice. Am J Cardiovasc Dis. 2017 Apr 15;7(2):33-47. Erratum in: Am J Cardiovasc Dis. 2017 Jul 25;7(4):97. PMID:28533928; PMCID: PMC5435603.
  5. Ramanathan N, Tan E, Loh LJ, Soh BS, Yap WN. Tocotrienol is a cardioprotective agent against ageing-associated cardiovascular disease and its associated morbidities. Nutr Metab (Lond). 2018
  6. Peng Z, Li X, Xing D, Du X, Wang Z, Liu G, Li X. Nobiletin alleviates palmitic acid‑induced NLRP3 inflammasome activation in a sirtuin 1‑dependent manner in AML‑12 cells. Mol Med Rep. 2018 Dec;18(6):5815-5822. doi: 10.3892/mmr.2018.9615. Epub 2018 Oct 31. PMID: 30387829.
  7. Wood G, Taylor E, Ng V, Murrell A, Patil A, van der Touw T, Wolden M, Andronicos N, Smart NA. Estimating the Effect of Aerobic Exercise Training on Novel Lipid Biomarkers: A Systematic Review and MultivariateReferences: